blue #
= weekly pop chart peak
| 1 | Nobody Else | Sep 1998 |  |
| 2 | Sweet Lady | 18 | Feb 1999 | |
| 3 | Lately | Jul 1999 | |
| 4 | Criminal Mind | Sep 1999 | |
| Tyrese Featuring Heavy D |
| 5 | The Best Man I Can Be | Mar 2000 | |
| Ginuwine, RL, Tyrese, Case |
| 6 | What'Chu Like | 8 | Jul 2000 | |
| Da Brat Featuring Tyrese |
| 7 | I Like Them Girls | Jun 2001 | |
| 8 | Just A Baby Boy | Jul 2001 | |
| Snoop Dogg Featuring Tyrese & Mr. Tan |
| 9 | What Am I Gonna Do | Oct 2001 | |
| 10 | How You Gonna Act Like That | 23 | Apr 2003 | |
| 11 | Pick Up The Phone | Aug 2003 | |
| Tyrese And Ludacris Featuring R. Kelly |
| 12 | Signs Of Love Makin' | Aug 2003 | |
| 13 | Pullin' Me Back | 8 | Sep 2006 | |
| Chingy Featuring Tyrese |
| 14 | Turn Ya Out | Feb 2007 | |
| Tyrese Featuring Lil Jon |
| 15 | One | Feb 2007 | |
| 16 | Too Easy | Oct 2011 | |
| Tyrese Featuring Ludacris |
| 17 | Stay | Nov 2011 | |
| 18 | Nothing On You | May 2012 | |
| 19 | Best Of Me | Mar 2013 | |
| 20 | Dumb Shxx | May 2015 | |
| Tyrese Featuring Snoop Dogg |
| 21 | Shame | Jul 2015 | |