brown #
= weekly rock chart peak
blue #
= pop chart peak
| 1 | It Wasn't Me | 1 | Dec 2000 |  |
| Shaggy Featuring Ricardo RikRok Ducent |
| 2 | Come On Over Baby (All I Want Is You) | 1 | Aug 2000 | |
| Christina Aguilera |
| 3 | Independent Women Part 1 | 1 | Nov 2000 | |
| Destiny's Child |
| 4 | Show Me The Meaning Of Being Lonely | 1 | Jan 2000 | |
| Backstreet Boys |
| 5 | Doesn't Really Matter | 1 | Jul 2000 | |
| Janet Jackson |
| 6 | Kryptonite | 1 | 1 | Sep 2000 | |
| 3 Doors Down |
| 7 | This I Promise You | 1 | Oct 2000 | |
| 'NSYNC |
| 8 | Bye, Bye, Bye | 1 | Feb 2000 | |
| 'NSYNC |
| 9 | Maria, Maria | 1 | Mar 2000 | |
| Santana Featuring The Product G&B |
| 10 | The Real Slim Shady | 6 | 1 | May 2000 | |
| Eminem |
| 11 | Thong Song | 1 | Mar 2000 | |
| Sisqo |
| 12 | All The Small Things | 1 | 1 | Jan 2000 | |
| Blink 182 |
| 13 | It's Gonna Be Me | 1 | May 2000 | |
| 'NSYNC |
| 14 | Jumpin, Jumpin | 1 | Jul 2000 | |
| Destiny's Child |
| 15 | Bent | 16 | 1 | Jul 2000 | |
| Matchbox 20 |
| 16 | Amazed | 1 | Feb 2000 | |
| Lonestar |
| 17 | With Arms Wide Open | 1 | 1 | Sep 2000 | |
| Creed |
| 18 | Case Of The Ex (Whatcha Gonna Do) | 1 | Nov 2000 | |
| Mya |
| 19 | Shape Of My Heart | 1 | Oct 2000 | |
| Backstreet Boys |
| 20 | Oops!... I Did It Again | 1 | Apr 2000 | |
| Britney Spears |
| 21 | Try Again | 1 | May 2000 | |
| Aaliyah |
| 22 | Say My Name | 1 | Mar 2000 | |
| Destiny's Child |
| 23 | Everything You Want | 3 | 3 | Apr 2000 | |
| Vertical Horizon |
| 24 | Most Girls | 2 | Oct 2000 | |
| Pink |
| 25 | He Loves U Not | 2 | Dec 2000 | |
| Dream |