blue #
= weekly pop chart peak
| 1 | Stay | Oct 2005 |  |
| Ne-Yo Featuring Peedi Peedi |
| 2 | So Sick | 1 | Feb 2006 | |
| 3 | When You're Mad | 17 | May 2006 | |
| 4 | Back Like That | May 2006 | |
| Ghostface Killah Featuring Ne-Yo |
| 5 | Feels So Good | Aug 2006 | |
| Remy Ma Featuring Ne-Yo |
| 6 | Sexy Love | 4 | Sep 2006 | |
| 7 | Because Of You | 14 | Apr 2007 | |
| 8 | Leaving Tonight | Jun 2007 | |
| Ne-Yo Featuring Jennifer Hudson |
| 9 | Sexual Healing | Jul 2007 | |
| Sarah Connor Featuring Ne-Yo |
| 10 | Do You | Aug 2007 | |
| 11 | Make Me Better | 8 | Sep 2007 | |
| Fabolous Featuring Ne-Yo |
| 12 | Can We Chill | Oct 2007 | |
| 13 | Hate That I Love You | 1 | Nov 2007 | |
| Rihanna Featuring Ne-Yo |
| 14 | Go On Girl | Apr 2008 | |
| 15 | Bust It Baby Pt. 2 | 16 | Jun 2008 | |
| Plies Featuring Ne-Yo |
| 16 | Closer | 1 | Jul 2008 | |
| 17 | Nobody | Sep 2008 | |
| 18 | Single | Oct 2008 | |
| New Kids On The Block Featuring Ne-Yo |
| 19 | Miss Independent | 5 | Nov 2008 | |
| 20 | Camera Phone | Jan 2009 | |
| The Game Featuring Ne-Yo |
| 21 | She Got Her Own | Mar 2009 | |
| Ne-Yo Featuring Jamie Foxx And Fabolous |
| 22 | Mad | 8 | Mar 2009 | |
| 23 | Part Of The List | Jul 2009 | |
| 24 | Sunshine | Jul 2009 | |
| Phyllisia Featuring Ne-Yo & Flo Rida |
| 25 | Knock You Down | 1 | Aug 2009 | |
| Keri Hilson Featuring Kanye West & Ne-Yo |
| 26 | What You Do | Sep 2009 | |
| Chrisette Michele Featuring Ne-Yo |
| 27 | Be On You | 16 | Oct 2009 | |
| Flo Rida Featuring Ne-Yo |
| 28 | Baby By Me | Nov 2009 | |
| 50 Cent Featuring Ne-Yo |
| 29 | Never Knew I Needed | Dec 2009 | |
| 30 | Angels Cry | Feb 2010 | |
| Mariah Carey Featuring Ne-Yo |
| 31 | Sign Your Name | May 2010 | |
| Michael Bolton Featuring Ne-Yo |
| 32 | Super High | Jun 2010 | |
| Rick Ross Featuring Ne-Yo |
| 33 | Beautiful Monster | 23 | Jul 2010 | |
| 34 | Champagne Life | Aug 2010 | |
| 35 | One In A Million | Dec 2010 | |
| 36 | Give Me Everything | 1 | Jun 2011 | |
| Pitbull Featuring Ne-Yo, Afrojack & Nayer |
| 37 | The Way You Move | Nov 2011 | |
| DJ Hard Hitta Featuring Ne-Yo, Trey Songz, T-Pain |
| 38 | No More | Jan 2012 | |
| LL Cool J Featuring Ne-Yo |
| 39 | Turn All The Lights On | Apr 2012 | |
| T-Pain Featuring Ne-Yo |
| 40 | Think Like A Man | Apr 2012 | |
| Jennifer Hudson & Ne-Yo Featuring Rick Ross |
| 41 | Leave You Alone | May 2012 | |
| Young Jeezy Featuring Ne-Yo |
| 42 | Let's Go | 3 | Aug 2012 | |
| Calvin Harris Featuring Ne-Yo |
| 43 | Lazy Love | Sep 2012 | |
| 44 | Let Me Love You (Until You Learn To Love Yourself) | 4 | Nov 2012 | |
| 45 | Don't Make Em Like You | Dec 2012 | |
| Ne-Yo Featuring Wiz Khalifa |
| 46 | Turn Around | Jan 2013 | |
| Conor Maynard Featuring Ne-Yo |
| 47 | Forever Now | Mar 2013 | |
| 48 | Should Be You | Apr 2013 | |
| Ne-Yo Featuring Fabolous & Diddy |
| 49 | She Is | May 2013 | |
| Ne-Yo Featuring Tim McGraw |
| 50 | Tonight | Jun 2013 | |
| Jessica Sanchez Featuring Ne-Yo |
| 51 | Reason To Hate | Jul 2013 | |
| DJ Felli Fel Featuring Ne-Yo, Tyga & Wiz Khalifa |
| 52 | Play Hard | 26 | Jul 2013 | |
| David Guetta Featuring Ne-Yo & Akon |
| 53 | Incredible | Dec 2013 | |
| Celine Dion With Ne-Yo |
| 54 | I Want To Come Home For Christmas | Dec 2013 | |
| 55 | Money Can't Buy | Jul 2014 | |
| Ne-Yo Featuring Jeezy |
| 56 | Integrity | Jan 2015 | |
| Ne-Yo Featuring Charisse Mills |
| 57 | Time Of Our Lives | 4 | Feb 2015 | |
| Pitbull & Ne-Yo |
| 58 | She Knows | 16 | Mar 2015 | |
| Ne-Yo Featuring Juicy J |
| 59 | Coming With You | May 2015 | |
| 60 | Religious/Ratchet Wit Yo Friends (Interlude) | May 2015 | |