blue #
= weekly pop chart peak
| 1 | Don't Know | Jul 1997 |  |
| 2 | Best Friend | Feb 2000 | |
| Puff Daddy Featuring Mario Winans |
| 3 | I Need A Girl (Part Two) | 1 | Jul 2002 | |
| P. Diddy & Ginuwine Featuring Loon, Mario Winans & Tammy Ruggieri |
| 4 | Crush On You | Jun 2003 | |
| Mr. Cheeks Featuring Mario Winans |
| 5 | Down For Me | Oct 2003 | |
| Loon Featuring Mario Winans |
| 6 | I Don't Wanna Know | 1 | Apr 2004 | |
| Mario Winans Featuring Enya & P. Diddy |
| 7 | Never Really Was | Jul 2004 | |
| Mario Winans Featuring Twista |
| 8 | This Is The Thanks I Get | Nov 2004 | |
| Mario Winans Featuring Black Rob |
| 9 | You're The One | Dec 2004 | |
| Guerilla Black Featuring Mario Winans |
| 10 | Through The Pain (She Told Me) | Sep 2007 | |
| Diddy Featuring Mario Winans |
| 11 | Hey Baby (After The Club) | Jan 2008 | |
| Ashanti Featuring Mario Winans |
| 12 | Forever | 2008 | |
| Timati Featuring Mario Winans |
| 13 | Dream | Nov 2009 | |
| Massiv Featuring Mario Winans |
| 14 | Mine | Oct 2010 | |
| Sahara Featuring Mario Winans |